The Clinical and Immunology Database (CIDB) stores data collected from participants in translational clinical cohorts at HU CFAR sites. Confidential clinical and epidemiological data is linked to study subjects and a REDCap (Research Electronic Data Capture) application allows for submission and review of scientific concept proposals and specimen requests. Individuals need to complete the request form and meet the regulatory requirements to access the CIDB. Contact Ed DeMers for questions regarding repository access.
Description of Database Samples:
Four clinical cohorts provide the majority of specimens in the repository for HU CFAR investigators, and all are linked to a relational database that has been constructed over the past CFAR funding period:
- HIV-infected chronic progressors: includes both treated and untreated individuals as well as longitudinal blood sampling pre- and post-treatment.
- HIV-infected spontaneous controllers: includes individuals with HIV RNA levels <2000 copies/mL despite not receiving antiretroviral therapy; approximately 1500 individuals have been recruited from the U.S. and throughout the world for this important cohort.
- HIV-negative individuals: includes 100 HIV-uninfected controls for basic science studies.
- The phenogenetic cohort, led by Dr. Philip De Jager from BWH, was launched in 2007 as a resource that provides fresh and stored biological samples from human subjects selected by demographic or genotypic features such as disease-associated risk allele. Currently there are 1750 self-declared healthy participants of different ethnicity for whom there are biological specimens stored, including DNA and genome-wide association genetic data. Participants are consented to donate longitudinal samples and samples are available upon request for investigators in the CFAR community.