Title: Improved inference for vaccine-induced immune responses via shape-constrained methods
Abstract: We study the performance of shape-constrained methods for evaluating immune response profiles from early-phase vaccine trials. The motivating problem for this work involves quantifying and comparing the IgG-binding immune responses to the first and second variable loops (V1V2 region) arising in HVTN 097 and HVTN 100 HIV vaccine trials. We consider unimodal and log-concave shape-...
This training session, sponsored by the HU CFAR Developmental & Mentoring Core, is presented by Dr. Martin S. Hirsch and moderated by Drs. Emily Hyle and Athe Tsibris.
Dr. Hirsch is a Professor of Medicine at Harvard Medical School and Physician at the MGH and editor-in-chief of the Journal of Infectious Diseases, a position held since 2003. He's also one of editors-in-chief for UpToDate, an online medical textbook, specializing in infectious diseases topics.