ABSTRACT: Network methods can be useful in design, monitoring, and analysis of cluster randomized trials for control of spread of viral infections. This usefulness grows out of the role of statistical network models in molecular epidemiology and their use to design cluster randomized trials. One way to increase the use of network science in epidemiological research is to develop...
Title: Improved inference for vaccine-induced immune responses via shape-constrained methods
Abstract: We study the performance of shape-constrained methods for evaluating immune response profiles from early-phase vaccine trials. The motivating problem for this work involves quantifying and comparing the IgG-binding immune responses to the first and second variable loops (V1V2 region) arising in HVTN 097 and HVTN 100 HIV vaccine trials. We consider unimodal and log-concave shape-...