Literature Review
Biology of Aging
2018
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
- Midlife Systemic Inflammation is Associated with Frailty in Later Life: The ARIC Study.
- Effect of Protein Intake on Lean Body Mass in Functionally Limited Older Men: A Randomized Clinical Trial.
- Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.
- Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.
2017
- Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study.
- Biomarker signatures of aging.
- Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?
- Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods.
- Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study.
- Aged interleukin-10tm1Cgn chronically inflamed mice have substantially reduced fat mass, metabolic rate, and adipokines.
2016
- Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
- Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity".
- Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats.
- Sarcopenia Trials in Specific Diseases: Report by the International Conference on Frailty and Sarcopenia Research Task Force.
- Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity.
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
- Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.
2015
- Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study.
- PHARMACOLOGICAL INTERVENTIONS IN FRAILTY AND SARCOPENIA: REPORT BY THE INTERNATIONAL CONFERENCE ON FRAILTY AND SARCOPENIA RESEARCH TASK FORCE.
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
- An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter?
2014
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.
- Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
- Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.
- Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.
- Stem cell aging: mechanisms, regulators and therapeutic opportunities.
- Patterns, predictors, and outcomes of falls trajectories in older adults: the MOBILIZE Boston Study with 5 years of follow-up.
- Regenerating skeletal muscle in the face of aging and disease.
≤ 2013
- Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. (Sept 2013)
- Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. (Dec 2013)
- Genetic signatures of exceptional longevity in humans (Jan 2012)
- The intersection between aging and cardiovascular disease (Apr 2012)
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. (Nov 2011)
- Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston Study. (May 2010)
- Effects of exercise on mobility in obese and nonobese older adults (June 2010)
- Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. (Sept 2010)
- Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice. (Sept 2009)
- Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. (Jan 2007)
- The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. (Oct 2006)
- Prognostic Value of Usual Gait Speed in Well‐Functioning Older People—Results from the Health, Aging and Body Composition Study. (Oct 2005)
- Ink4a/Arf expression is a biomarker of aging. (Nov 2004)
- Centenarians as a model for healthy aging. (Apr 2003)
- Catabolism of aging: is it an inflammatory process? - NCBI (May 2003)
- Human Aging, Muscle Mass, and Fiber Type Composition. (Nov 1995)
- Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. (Apr 1992)
HIV and Aging
2018
2017
2016
- Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA
- Geriatric Assessments And Association With Vacs Index Among Hiv-Infected Older Adults In San Francisco
- The neurobiology of HIV and its impact on cognitive reserve: A review of cognitive interventions for an aging population.
- HIV and ageing: improving quantity and quality of life.
2015
- Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults
- Acceleration of age-associated methylation patterns in HIV-1-infected adults.
- Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively.
- Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects.
- HIV-1 Infection Accelerates Age According to the Epigenetic Clock.
- Accelerated Longitudinal Gait Speed Decline in HIV-Infected Older Men
- Elevated Biomarkers of Inflammation and Coagulation in Patients with HIV Are Associated with Higher Framingham and VACS Risk Index Scores
- Mitochondrial DNA mutations in ageing and disease: implications for HIV?
2014
- Cognitive Functioning in Adults Aging with HIV: A Cross-Sectional Analysis of Cognitive Subtypes and Influential Factors.
- Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men.
- The VACS index predicts mortality in a young, healthy HIV population starting highly active antiretroviral therapy.
- Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.
- Is HIV a model of accelerated or accentuated aging?
- Relationship of Physical Function and Quality of Life among Persons Aging with HIV Infection
- An adapted frailty-related phenotype and the VACS index as predictors of hospitalization and mortality in HIV-infected and uninfected individuals.
2013
- Predictive accuracy of the Veterans Aging Cohort Study index for mortality with HIV infection: a North American cross cohort analysis
- Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease.
- Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy.
- Association of the veterans aging cohort study index with exercise capacity in HIV-infected adults
- Systemic effects of inflammation on health during chronic HIV infection.
≤ 2012
- HIV and aging--preparing for the challenges ahead (Apr 2012)
- Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV (Apr 2012)
- Premature expression of a muscle fibrosis axis in chronic HIV infection (June 2012)
- HIV and Aging: State of Knowledge and Areas of Critical Need for Research: A report to the NIH Office of AIDS Research by the HIV and Aging Working Group (July 2012)
- Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy. (Nov 2012)
- Association of age and comorbidity with physical function in HIV-infected and uninfected patients: results from the Veterans Aging Cohort Study. (Jan 2011)
- HIV infection, inflammation, immunosenescence, and aging (Feb 2011)
- Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations (June 2011)
- HIV and aging: time for a new paradigm (May 2010)
- Premature aging of T cells is associated with faster HIV-1 disease progression. (Feb 2009)
- Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. (Aug 2009)
- Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. (June 2008)
- Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. (Aug 2008)
- Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. (July 2007)
- HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. (Nov 2007)
≤ 2012
- HIV and aging--preparing for the challenges ahead (Apr 2012)
- Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV (Apr 2012)
- Premature expression of a muscle fibrosis axis in chronic HIV infection (June 2012)
- HIV and Aging: State of Knowledge and Areas of Critical Need for Research: A report to the NIH Office of AIDS Research by the HIV and Aging Working Group (July 2012)
- Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy. (Nov 2012)
- Association of age and comorbidity with physical function in HIV-infected and uninfected patients: results from the Veterans Aging Cohort Study. (Jan 2011)
- HIV infection, inflammation, immunosenescence, and aging (Feb 2011)
- Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations (June 2011)
- HIV and aging: time for a new paradigm (May 2010)
- Premature aging of T cells is associated with faster HIV-1 disease progression. (Feb 2009)
- Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. (Aug 2009)
- Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. (June 2008)
- Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. (Aug 2008)
- Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. (July 2007)
- HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. (Nov 2007)