The MATCH Study of HIV and Aging

  • Principal Investigator(s): Monty Montano
  • Study Contact: Brooke Ferguson Brawley; BBRAWLEY@PARTNERS.ORG617-525-9195
  • Description of Subjects: Adult males and females, 50-65 years old. If HIV+, on effective ART.
  • Location (Domestic vs. International): Boston Metropolitan Area
  • Enrollment Period: 2015-2016
  • Enrollment Goal: 200
  • Key Exclusion and Inclusion Criteria: Must have a CD4 count > 350 cells/mm3 and HIV viral load < 200 copies/ml. Lower extremity mobility sufficient to participate in functional assessment
  • Available Biological Specimens: Blood, serum, or plasma; Peripheral Blood Mononuclear Cells; Tissues and Stool; Other (Muscle tissue)
  • How to Request AccessContact Brooke Ferguson Brawley, BBRAWLEY@PARTNERS.ORG
  • Available Data Description: multiple immune and muscle parameters
  • Optional Additional Comments:  This is a non-randomized observational longitudinal study design. We will recruit HIV infected adults (50 to 65 years old) and demographically matched uninfected control subjects to be followed for 4 years in this 5 year study. Total enrollment will be 200 subjects. The targeted age range of 50-65 is chosen to evaluate aging HIV infected individuals at risk for early frailty in the United States. Primary outcomes are measurement of a) inflammation, b) biomarkers for aging, c) CT scans of the mid-thigh, d) fibrosis in muscle and e) levels of physical function ability.